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Posts: 1
Reply with quote  #1 
How safe is it to take Whey protein isolate like immunocal for people suffering from reduced renal function. I am not talking about those on dialysis.

I am getting conflicting information and need morre supporting data.

In addition , like in the case of Immunocal Platinum that has creatine how does the combination of the two effects the kidneys an liver for this matter.


Posts: 8
Reply with quote  #2 
Hi Jason,

Hard question to answer.  I suggest you check this further but I came across a warning related to Whey protein concentrate which is slightly different than whey protein Isolate.  

You can also access that site you self at:


Also known as:
Whey protein concentrates (WPC), Immunocal, Protectamin
What is it?
Whey results when liquid is drained from the curd during the making of cheese. It contains lactose, protein, ash and lipids. The protein concentration at this stage of processing is about 67%. Whey proteins can be further processed to yield whey protein concentrates (WPC). The protein concentration can be as high as 95% after the removal of the fats and lactose. WPC’s are high in lactalbumin, minerals and vitamins. WPC’s have been used in a wide range of food products such as dairy foods, egg white replacement, drinks, imitation seafood and meat products. Whey protein is added to infant formula to more closely imitate human milk.
Adverse Events:
Persons allergic to milk protein should not take whey protein. Poor quality formulas may cause gas and bloating. Taking too much may cause liver and kidney damage. Drinking large amounts of water may help prevent liver and kidney damage.
Levodopa taken at the same time as whey protein may decrease the absorption of the medication. Whey protein can decrease the absorption of some drugs like fluoride (Fluoritab), fluoroquinolones, tetracyclines and alendronate (Fosamax). To stop this from happening, wait at least two (2) hours between taking these drugs and taking whey protein.
Safety and Effectiveness:
Persons with kidney disease should not take whey protein.
History of use:
Whey protein concentrates contain a wide-range and near full-blend of essential and non-essential amino acids. Amino acids are commonly referred to as the building blocks of life. Amino acids combine to form proteins. These proteins make up nearly every tissue and organ in the body. Adding proteins to the diet may help to repair injuries, to help metabolism, and to improve general health. The real nutritional value of WPC’s lies in their large amount of amino acids. For example, the typical WPC contains up to 18 amino acids, which is almost the full blend. Studies have shown that whey protein can increase the amount of glutathione in the blood. Glutathione is an antioxidant, which is important to a healthy immune system. Persons with HIV and the elderly have decreased glutathione levels and also weakened immune systems. This is why whey protein has become of interest in immune-suppressed populations.

Other References


21 CFR 184.1979c


Posts: 5
Reply with quote  #3 
One more inportant comment.

It takes a lot of water to metabolize protein, Including Whey protein. To avoid dehydration that can cause further damage to the kidney while the protein is being digested, you may help your kidneys by drinking 8 or more 8 oz. glasses of water a day.


Posts: 2
Reply with quote  #4 
Immunotec , the Immunocal manufacturer also produces ProNutra a hospital and nursing home grade Whey protein Isolate. Here is what they have to say about it in reference to renal function:

Are there any adverse reactions from taking ProNutra?

Because ProNutra contains whey protein, high doses of whey protein from 2.3 or more g/kg/day can cause increased stool frequency, nausea, thirst, bloating, cramps, reduced appetite, fatigue, and headache. Whey protein, in addition to a normal diet, can also increase blood urea nitrogen (BUN) levels twofold.  However, whey protein does not change serum creatinine, indicating that the effect is due to protein loading, rather than reduced renal function
This is significant and it means that renal patients have to seriously count the amount of Whey protein they consume and in some cases may have to reduce other protein intake.

Posts: 8
Reply with quote  #5 
Just wanted to add one more factor. One might have a low creatinine level due to diabetes. So in case you might have diabetes and moderate renal failure the diabetes night bring the creatinine down artificially simply because less creatinien will be created in the blood to start with.

To understanbd more please read the following study:

Low Creatinine Linked to Diabetes

- Mescape

Anthony J. Brown, MD
Disclosure: Anthony J. Brown, MD, has disclosed no relevant financial relationships.

Désirée Lie, MD, MSEd
Disclosure: Désirée Lie, MD, MSEd, has disclosed no relevant financial relationships.

Brande Nicole Martin
Disclosure: Brande Nicole Martin has disclosed no relevant financial information.

March 13, 2009 — Lower serum levels of creatinine are associated with increased risk of type 2 diabetes, according to a brief report in the March issue of Diabetes Care.

The authors note that creatinine in serum is a direct indicator of total muscle mass. “Although skeletal muscle is one of the major targets of insulin,” write Dr. Tomoshige Hayashi, from Osaka City University Graduate School of Medicine, Japan, and colleagues, “to our knowledge, no prospective study has investigated the association between total skeletal muscle mass and type 2 diabetes.”

The current investigation included 8570 men in the Kansai Healthcare Study, an ongoing project examining risk factors for cardiometabolic diseases. The participants were between 40 and 55 years of age and nondiabetic at entry.

Incident diabetes was diagnosed if fasting glucose levels reached 126 mg/dL or higher or if treatment with an oral hypoglycemic agent or insulin was initiated.

After 4 years of follow-up, 877 men were diagnosed with type 2 diabetes. “The multiple-adjusted odds ratio for those who had serum creatinine between 0.40 and 0.60 mg/dL was 1.91 compared with those who had levels between 0.71 and 0.80 mg/dL,” the investigators report.

They conjecture that, because resistance training is known to cause muscular hypertrophy, it might be worth exploring whether such training could increase creatinine levels and thereby cut the risk of diabetes.

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